<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3270 3270-30703 France 2003 HIV1 F Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, T69D, K70R, L74I, M184V, T215F K219Q, N348I   V108I, F227L I2V, T27TS, V35T, T39K, K43Q, V60I, D121Y, K122E, I135V, S162C, K173T, Q174K, D177E, V179I, G196E, E203K, Q207A, R211A, K223E, L228H, V245K, E248D, D250DE, S251I, A272P, T286A, E291D, V292VI, I293V, E297D, A327V, I341F, A355G, R356K, G359S, A376S, T377L, T386I, K390R, Q394L, E399D  
>3270-30703| codons 1-399
PVSPIETVPVKLKPGMDGPKVKQWPLSEEKIKALTEICKEMEQEGKISKIGPENPYNTPI
FAIKKKNSDRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTILDVGDAYFSVPL
YEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRTKNPEIII
YQYVDDLYVGSDLEIEQHRTKIKELRAHLLAWGFFTPDQKHQEEPPLHWMGYELHPDKWT
VQPIKLPDKEIWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVPLTDEAE
LELAENREILKEPVHGVYYDPSKDLIVEIQKQGQGQWTYQFYQEPFKILKTGKYGKMRSA
HTNDVKQLTEAVQKISLESIVIWGKIPKFRLPILKETWD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A, L90M F53FL L10I, I15V, K20R, E35D, M36I, N37E, K55R, R57K, I62V, L63A, A71V, L89I, I93L  
>3270-30703| codons 1-99
PQITLWQRPIVTIKVGGQLREALLDTGADDTVLEDIELPGRWKPKLIGGIGGLVRVKQYD
QVAIEICGHKVIGTVLVGPTPANIIGRNIMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006