Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3270 | 3270-30703 | France | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | F53FL | L10I, I15V, K20R, E35D, M36I, N37E, K55R, R57K, I62V, L63A, A71V, L89I, I93L |
| >3270-30703| codons 1-99 PQITLWQRPIVTIKVGGQLREALLDTGADDTVLEDIELPGRWKPKLIGGIGGLVRVKQYD QVAIEICGHKVIGTVLVGPTPANIIGRNIMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, L74I, M184V, T215F | K219Q, N348I | V108I, F227L | I2V, T27TS, V35T, T39K, K43Q, V60I, D121Y, K122E, I135V, S162C, K173T, Q174K, D177E, V179I, G196E, E203K, Q207A, R211A, K223E, L228H, V245K, E248D, D250DE, S251I, A272P, T286A, E291D, V292VI, I293V, E297D, A327V, I341F, A355G, R356K, G359S, A376S, T377L, T386I, K390R, Q394L, E399D |
| >3270-30703| codons 1-399 PVSPIETVPVKLKPGMDGPKVKQWPLSEEKIKALTEICKEMEQEGKISKIGPENPYNTPI FAIKKKNSDRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTILDVGDAYFSVPL YEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRTKNPEIII YQYVDDLYVGSDLEIEQHRTKIKELRAHLLAWGFFTPDQKHQEEPPLHWMGYELHPDKWT VQPIKLPDKEIWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVPLTDEAE LELAENREILKEPVHGVYYDPSKDLIVEIQKQGQGQWTYQFYQEPFKILKTGKYGKMRSA HTNDVKQLTEAVQKISLESIVIWGKIPKFRLPILKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |