Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3268 | 3268-30728 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I50L, I54V, V82A, L90M | K43T, F53L | L10IV, I15IV, G16A, K20R, E35D, M36I, K55R, D60E, I62V, L63P, A71V, I93L, C95F |
| >3268-30728| codons 1-99 PQITLWQRPVVTIKVAGQLREALLDTGADDTVLEDINLPGRWTPKLIGGLGGLVRVRQYE QVPIEICGHKVIGTVLVGPTPANIIGRNLMTQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74IV, Y115YF, M184V, L210W, T215Y | Y181YC, G190GA | K43E, V118VI, I135V, S162C, V179VI, T200TA, R211IK, L228H, V245E, A272P, K277R, D324E, G359GS, K366R, A376S, K390KR |
| >3268-30728| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEEGKISKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAFFSIPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIII CQYVDDLYVASDLEIGQHRAKIEELRQHLWKWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVRQLTEAVQKISTESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |