Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3266 | 3266-30729 | France | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, L74I, M184V, T215F | K219Q | K103S, Y181C, G190A | A98G | P4S, K20KR, V35T, T69N, K122E, D123E, I135L, E138EQ, T165I, I167V, E169EQ, K173A, Q174K, D177E, I178L, V179T, T200A, I202V, E204A, Q207E, R211K, D218E, P243T, V245Q, E248D, D250S, A272P, K275R, T286A, E291D, I293V, E297A, L303M, D324DE, I329V, F346H, R356RK, M357R, G359S, K366R, A371V, S379G, T386I, K390R, E399D |
| >3266-30729| codons 1-399 PISSIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSNRWRKIVDFRELNKRTQDFWEVQLGIPHPGGLKKSKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSLNNQTPGIRYQYNVLPQGWKGSPAIFQSSMIKVLQPFRAKNPELTI CQYVDDLYVASDLEIGQHRAKVEALREHLLKWGFFTPEQKHQKEPPFLWMGYELHPDKWT VQTIQLPDKSSWTVNDIQKLVGKLNWASQIYPGIRVKQLCKLLRGAKALTDVVPLTAEAE LEMAENREILKEPVHGVYYDPSKELIAEVQKQGQGQWTYQIYQEPHKNLKTGKYAKRRSA HTNDVRQLTEVVQKIATEGIVIWGKIPKFRLPIQKETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A | V11VI, L24I, L33F, L89V | L10I, I15V, K20A, E35DN, M36L, N37Q, R41K, K55R, R57RK, D60E, Q61E, I62V, L63P, I64L, A71V, I72M, V77I, T91S, I93L |
| >3266-30729| codons 1-99 PQITLWQRPIITIKVGGQLAEALIDTGADDTVFENLQLPGKWKPKIIGGIGGFVRVKQYE EVPLEICGHKVMGTVLIGPTPANIIGRNVLSQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |