<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3266 3266-30729 France 2003 HIV1 F Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A V11VI, L24I, L33F, L89V L10I, I15V, E35DN, M36L, N37Q, R41K, K55R, R57RK, D60E, Q61E, I62V, L63P, I64L, A71V, I72M, V77I, T91S, I93L K20A
>3266-30729| codons 1-99
PQITLWQRPIITIKVGGQLAEALIDTGADDTVFENLQLPGKWKPKIIGGIGGFVRVKQYE
EVPLEICGHKVMGTVLIGPTPANIIGRNVLSQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, K70R, L74I, M184V, T215F K219Q K103S, Y181C, G190A A98G P4S, K20KR, V35T, T69N, K122E, D123E, I135L, E138EQ, T165I, I167V, E169EQ, K173A, Q174K, D177E, I178L, V179T, T200A, I202V, E204A, Q207E, R211K, D218E, P243T, V245Q, E248D, D250S, A272P, K275R, T286A, E291D, I293V, E297A, L303M, D324DE, I329V, F346H, R356RK, M357R, G359S, K366R, A371V, S379G, T386I, K390R, E399D  
>3266-30729| codons 1-399
PISSIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV
FAIKKKNSNRWRKIVDFRELNKRTQDFWEVQLGIPHPGGLKKSKSVTVLDVGDAYFSVPL
DEEFRKYTAFTIPSLNNQTPGIRYQYNVLPQGWKGSPAIFQSSMIKVLQPFRAKNPELTI
CQYVDDLYVASDLEIGQHRAKVEALREHLLKWGFFTPEQKHQKEPPFLWMGYELHPDKWT
VQTIQLPDKSSWTVNDIQKLVGKLNWASQIYPGIRVKQLCKLLRGAKALTDVVPLTAEAE
LEMAENREILKEPVHGVYYDPSKELIAEVQKQGQGQWTYQIYQEPHKNLKTGKYAKRRSA
HTNDVRQLTEVVQKIATEGIVIWGKIPKFRLPIQKETWD

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006