<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3264 3264-40322 France 2004 HIV1 CRF45_cpx Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA
2 NRTI+NNRTI+RTV+TPV 38

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M L10F, L89V I13V, G16E, K20L, M36I, D60E, Q61H, L63R, I66V, H69K, K70R, A71T, P79A, I93L, C95V L23M
>3264-40322| codons 1-99
PQITLWQRPFVTVKIEGQLLEAMLDTGADDTVLEEINLPGRWKPKIIGGIGGFVKVRQYE
HIRIEVCGKRTIGTVLVGATPVNVIGRNVMTQLGVTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, M184V, L210W, T215Y   K103KN, Y181C   E6K, V35T, T39M, V118I, K122E, I135T, S162C, K173A, Q174K, D177E, Q207E, R211K, V241VM, V245Q, E248D, D250E, A272P, K281R, T286A, E291D, V292I, I293V, E297A, K311KR, V317A, D324E, I329V, G335D, F346Y, M357T, G359S, T369A, T377Q, K390R, A400T  
>3264-40322| codons 1-400
PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICMELEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRAKNPEIVI
CQYVDDLYVGSDLEIGQHRTKIEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
MQPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGAKALTDIVPLTAEAE
LELAENREILREPVHGAYYDPSKELIAEVQKQGQDQWTYQIYQEPYKNLKTGKYARTRSA
HTNDVKQLAEAVQKIAQESIVIWGKTPKFRLPIQKETWET

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006