<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3264 3264-30703 France 2003 HIV1 CRF45_cpx Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M L10F, L89V I13V, K14KR, G16E, K20L, M36I, D60E, Q61H, L63R, I66V, H69K, K70R, A71T, P79A, I93L, C95F  
>3264-30703| codons 1-99
PQITLWQRPFVTVRIEGQLLEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFVKVRQYE
HIRIEVCGKRTIGTVLVGATPVNVIGRNVMTQLGFTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, M184V, L210W, T215Y       E6K, V35T, T39M, V118I, K122E, I135T, S162C, K173A, Q174K, D177E, Q207E, R211K, V245Q, E248D, D250E, A272P, K281R, T286A, E291D, V292I, I293V, E297A, K311KR, V317A, D324E, I329V, G335D, F346Y, M357T, G359S, T377Q, K390R, A400T  
>3264-30703| codons 1-400
PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICMELEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRAKNPEIVI
YQYVDDLYVGSDLEIGQHRTKIEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGAKALTDIVPLTAEAE
LELAENREILREPVHGAYYDPSKELIAEVQKQGQDQWTYQIYQEPYKNLKTGKYARTRSA
HTNDVKQLTEAVQKIAQESIVIWGKTPKFRLPIQKETWET

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006