Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3263 | 3263-30728 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82S | L24I, F53FL | L10I, R41K, L63P, I64M, A71V, V77I, I93L | E34DY, M36M_DL |
| >3263-30728| codons 1-99 PQITLWQRPIVTIKIGGQLKEALIDTGADDTVLYEMNLPGKWKPKIIGGIGGLVKVRQYD QIPMEICGHKVIGTVLIGPTPSNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | K219N | V118I, K122E, Q207E, R211K, V245K, S251H, A272P, A288S, L289I, I293V, V317VA, R358K, G359S, A371V, T377Q |
| >3263-30728| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELREHLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIKLPEKDHWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKSITEVVPLTEEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMKSA HTNDVKQLTEVVQKIAQESIVIWGKTPKFKLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |