Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3262 | 3262-30729 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | G73S | L10I, I15V, Q18H, K20I, E35D, M36I, N37D, K55R, R57RK, I62V, L63P, C67F, H69K, A71V, I85V, Q92E, I93M | C95CG |
| >3262-30729| codons 1-99 PQITLWQRPIVTIKVGGHLIEALLDTGADDTVLEDIDLPGRWKPKIIGGIGGFVRVKQYD QVPIEIFGKKVISTVLVGPTPVNVVGRNLMTEMGGTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, M184V, L210LRW, T215Y | K219Q | K103N | K20KR, V35VL, E44D, V60I, K64R, K122E, Q174K, N175Y, D177N, I195L, G196E, T200TAEK, H208HY, R211A, D218E, L228H, V245T, R284K, A288T, I293V, E297K, V317VM, D324E, I329L, M357T, G359S, S379SG |
| >3262-30729| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICTELEKDGKISKIGPENPYNTPI FAIRKKNSTRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKYPNIVI YQYVDDLYVGSDLELEQHRKKIEELRQYLWAWGFYTPEQKHQKEPPFHWMGYELHPDKWT VQPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGTKTLTEVVPLTKEAE LELAENREILKEPVHGMYYDPSKELIAELQKQGQGQWTYQIYQEPFKNLKTGKYARTRSA HTNDVKQLTEAVQKIATEGIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |