Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3261 | 3261-30728 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, L74I, Y115F, Q151M, M184V | A62V, V75I, K219E | L100I, K103N | V35I, K122E, I135T, I178IM, T200A, R211K, F214L, D237DE, I293V, E297K, I326V, I329L, V365I, V381I, T386I, K390R |
| >3261-30728| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV FVIKKKNSTKWRKIIDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAFFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYVDDLYVGSDLEIGQHRAKIEELRQHLLKWGLTTPDEKHQKEPPFLWMGYELHPEKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLVAELQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA HTNDIKQLTEAVQKIATESIIIWGKIPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82F | K43T, T74P | L10I, I13V, I15V, L19I, K20T, E35N, M36I, N37S, I62V, L63V, I64V |
| >3261-30728| codons 1-99 PQITLWQRPIVTVKVGGQITEALLDTGADDTVLENISLPGRWTPKMIGGIGGFVKVRQYD QVVVEICGHKAIGPVLVGPTPFNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |