Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3260 | 3260-30630 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L210W, T215Y | K219R | A98G | I5IV, E44D, V118I, K122E, S162C, E203D, H208Y, R211K, K223Q, L228H, V245M, A272P, T286A, I293V, I326V, Q334E, F346Y, G359S, T377M, T386TI, K390R |
| >3260-30630| codons 1-399 PISPVETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIDELRQYLWKWGFYTPDRKHQQEPPFHWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLVAEIQKQGEGQWTYQIYQEPYKNLKTGKYARMRSA HTNDVKQLTEAVQKIAMESIVIWGKIPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I50V, I54S, V82A | L10I, I15V, L19I, K20R, E35D, M36I, N37DE, I64IV, A71V, I93M |
| >3260-30630| codons 1-99 PQITLWQRPIVTIKVGGQIREALLDTGADDTVLEDIELPGRWKPKMIVGVGGFSKVRQYD QILVEICGHKVIGTVLVGPTPANIIGRNLLTQMGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |