Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3257 | 3257-30710 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | L10F, V11I, Q58E, G73S | I13V, I15V, K20I, M36I, D60E, Q61E, I62V, L63P, A71V, I72T |
| >3257-30710| codons 1-99 PQITLWQRPFITVKVGGQLIEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFVKVREYE EVPIEICGHKVTSTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, T215F | K219Q | K20R, V35I, K101Q, K122E, K166R, G196E, I202V, L228H, V245K, A272P, L283I, I293V, E297K, K311KR, G333GE, P345PL, R356K, G359S, A360T, K366R, A371V, S379G, K390R |
| >3257-30710| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRTKVEELRQHLLRWGFFTPDQKHQKEPPFHWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGTKALTEVVPLTKEAE LELAENREILREPVHGVYYDPSKDLIAEIQKQEQGQWTYQIYQELFKNLKTGKYAKMRST HTNDVRQLTEVVQKIATEGIVIWGKTPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |