<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3256 3256-30702 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, V75M, L210W, T215Y D67E, N348I K101E   K20R, K43Q, S68G, V90I, I94L, A98S, K104KR, V118I, K122E, I135R, S162N, I178L, H208Y, R211K, L228H, A272P, I293V, E297A, I329L, A355G, M357T, G359S, A376T, S379SC, V381I, E399D  
>3256-30702| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEQEGKISKIGPENPYNTPV
FAIKKKEGTKWRKLMDFRELNKRTQDFWEIQLGLPHPSGLEKKRSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSRNNETPGIRYQYNVLPQGWKGSPAIFQNSMTKILEPFRKQNPDLVI
YQYMDDLYVGSDLEIGQHRTKIEELRQYLWKWGFYTPDKKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTAEAE
LELAENREILKEPVHGVYYDPSKDLIAELQKQGQGQWTYQIYQEPFKILKTGKYGRTRSA
HTNDVKQLTEAVQKITTECIIIWGKTPKFKLPIQKETWD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A, L90M L10F, V11I, G73S I13V, Q18H, K20I, M36I, N37D, I62V, L63P, A71V, I72L  
>3256-30702| codons 1-99
PQITLWQRPFITVKIGGHLIEALLDTGADDTVLEEIDLPGRWKPKIIGGIGGFVKVRQYD
QVPIEICGHKVLSTVLVGPTPANIIGRNLMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006