Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3256 | 3256-30702 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | L10F, V11I, G73S | I13V, Q18H, K20I, M36I, N37D, I62V, L63P, A71V, I72L |
| >3256-30702| codons 1-99 PQITLWQRPFITVKIGGHLIEALLDTGADDTVLEEIDLPGRWKPKIIGGIGGFVKVRQYD QVPIEICGHKVLSTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, V75M, L210W, T215Y | D67E, N348I | K101E | K20R, K43Q, S68G, V90I, I94L, A98S, K104KR, V118I, K122E, I135R, S162N, I178L, H208Y, R211K, L228H, A272P, I293V, E297A, I329L, A355G, M357T, G359S, A376T, S379SC, V381I, E399D |
| >3256-30702| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEQEGKISKIGPENPYNTPV FAIKKKEGTKWRKLMDFRELNKRTQDFWEIQLGLPHPSGLEKKRSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSRNNETPGIRYQYNVLPQGWKGSPAIFQNSMTKILEPFRKQNPDLVI YQYMDDLYVGSDLEIGQHRTKIEELRQYLWKWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAELQKQGQGQWTYQIYQEPFKILKTGKYGRTRSA HTNDVKQLTEAVQKITTECIIIWGKTPKFKLPIQKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |