Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3255 | 3255-30625 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70KR, V75T, M184V, T215Y | K219E | K103N, Y181C, G190GA | V108I, K238KT | E6D, K20R, K122E, D123N, I142V, D177E, V179I, G196E, E203K, Q207E, H208HY, L210Y, R211K, D218E, H221Y, L228H, R284K, A288S, I293V, E297R, I329L, M357S, A376T, T386I |
| >3255-30625| codons 1-399 PISPIDTVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLTDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPL DENFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIII CQYVDDLYVASDLEIEQHRTKIKELREYLYKWGFYTPEEKYQKEPPFHWMGYELHPDTWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGTKSLTEVVPLTREAE LELAENREILKEPVHGVYYDPSKDLIAELQKQGQGQWTYQIYQEPFKNLKTGKYARSRGA HTNDVKQLTEAVQKITTESIVIWGKIPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54S, V82M, L90M | L33F | L10V, I13V, I15V, K20R, E34EV, E35D, M36I, N37S, R41K, K55N, L63PT, A71V, V77VI, L89I, I93L |
| >3255-30625| codons 1-99 PQITLWQRPVVTVKVGGQLREALLDTGADDTVFVDISLPGKWKPKMIGGIGGFSNVRQYD QITIEICGHKVIGTVLIGPTPMNIIGRNIMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |