<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3255 3255-30625 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54S, V82M, L90M L33F L10V, I13V, I15V, K20R, E34EV, E35D, M36I, N37S, R41K, K55N, L63PT, A71V, V77VI, L89I, I93L  
>3255-30625| codons 1-99
PQITLWQRPVVTVKVGGQLREALLDTGADDTVFVDISLPGKWKPKMIGGIGGFSNVRQYD
QITIEICGHKVIGTVLIGPTPMNIIGRNIMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70KR, V75T, M184V, T215Y K219E K103N, Y181C, G190GA V108I, K238KT E6D, K20R, K122E, D123N, I142V, D177E, V179I, G196E, E203K, Q207E, H208HY, L210Y, R211K, D218E, H221Y, L228H, R284K, A288S, I293V, E297R, I329L, M357S, A376T, T386I  
>3255-30625| codons 1-399
PISPIDTVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV
FAIKKKNSTRWRKLTDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPL
DENFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIII
CQYVDDLYVASDLEIEQHRTKIKELREYLYKWGFYTPEEKYQKEPPFHWMGYELHPDTWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGTKSLTEVVPLTREAE
LELAENREILKEPVHGVYYDPSKDLIAELQKQGQGQWTYQIYQEPFKNLKTGKYARSRGA
HTNDVKQLTEAVQKITTESIVIWGKIPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006