<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3254 3254-30610 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69D, L74V, L210W, T215Y D67G, K219R K101E, Y181C, G190A A98G, V108I, F227L K20R, K43E, E44D, V118I, K122E, I142V, D177E, I178M, E203K, Q207D, H208Y, R211K, K223E, L228R, A272P, K277R, I293IV, E297A, D324E, I326V, I329IL, R356K, E370D, T377M, K385KR, K390R, E399D  
>3254-30610| codons 1-400
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEEDGKISKIGPENPYNTPV
FAIKKKGSDKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLEKKKSVTILDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI
CQYMDDLYVASDLEIGQHRTKIKELRDYLWKWGFYTPDRKHQEEPPLRWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTAEAE
LELAENREILKEPVHGVYYDPSKELVAELQKQGQGQWTYQIYQEPFKNLKTGKYAKMRGA
HTNDVKQLTDAVQKIAMESIVIWGRTPKFRLPIQKETWDA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I47A, L90M L23I, F53FL L10I, I15V, K20T, E35N, M36I, N37D, I62V, L63P, I66IV, A71L, I72V, V77I, I93L  
>3254-30610| codons 1-99
PQITLWQRPIVTIKVGGQLTEAILDTGADDTILENIDLPGRWKPKIAGGIGGLIKVRQYD
QVPIEVCGHKLVGTVLIGPTPVNIIGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006