Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3254 | 3254-30610 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47A, L90M | L23I, F53FL | L10I, I15V, K20T, E35N, M36I, N37D, I62V, L63P, I66IV, A71L, I72V, V77I, I93L |
| >3254-30610| codons 1-99 PQITLWQRPIVTIKVGGQLTEAILDTGADDTILENIDLPGRWKPKIAGGIGGLIKVRQYD QVPIEVCGHKLVGTVLIGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, L74V, L210W, T215Y | D67G, K219R | K101E, Y181C, G190A | A98G, V108I, F227L | K20R, K43E, E44D, V118I, K122E, I142V, D177E, I178M, E203K, Q207D, H208Y, R211K, K223E, L228R, A272P, K277R, I293IV, E297A, D324E, I326V, I329IL, R356K, E370D, T377M, K385KR, K390R, E399D |
| >3254-30610| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEEDGKISKIGPENPYNTPV FAIKKKGSDKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLEKKKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI CQYMDDLYVASDLEIGQHRTKIKELRDYLWKWGFYTPDRKHQEEPPLRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTAEAE LELAENREILKEPVHGVYYDPSKELVAELQKQGQGQWTYQIYQEPFKNLKTGKYAKMRGA HTNDVKQLTDAVQKIAMESIVIWGRTPKFRLPIQKETWDA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |