<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3253 3253-30710 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L210W, T215Y K219R K103N   V35VI, T39A, K43Q, E44D, E53D, V60VI, K102Q, V118I, K122E, G196E, I202IV, H208Y, H221Y, A272P, A288S, V292I, K311R, D324E, G333E, Q343H, M357T, T369A, A371V, K390R, K395R  
>3253-30710| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAELEQDGKISKIGPDNPYNTPI
FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKQNKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIEQHRTKVEELRQYLWRWGFYTPDRKYQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKSLTEIIPLTEEAE
LELAENREILREPVHGVYYDPSKELIAEIQKQEQGQWTYQIYHEPFKNLKTGKYARTRGA
HTNDVKQLAEVVQKIATESIVIWGKTPKFRLPIQRETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I50V, I54IV, V82A, L90M K43T L10I, K20R, E35D, M36I, D60E, I62V, L63P, A71V, I72T  
>3253-30710| codons 1-99
PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDINLPGRWTPKIIGGVGGFVKVRQYE
QVPIEICGHKVTGTVLVGPTPANIIGRNLMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006