Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3253 | 3253-30710 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V, I54IV, V82A, L90M | K43T | L10I, K20R, E35D, M36I, D60E, I62V, L63P, A71V, I72T |
| >3253-30710| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDINLPGRWTPKIIGGVGGFVKVRQYE QVPIEICGHKVTGTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L210W, T215Y | K219R | K103N | V35VI, T39A, K43Q, E44D, E53D, V60VI, K102Q, V118I, K122E, G196E, I202IV, H208Y, H221Y, A272P, A288S, V292I, K311R, D324E, G333E, Q343H, M357T, T369A, A371V, K390R, K395R, A400T |
| >3253-30710| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAELEQDGKISKIGPDNPYNTPI FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKQNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRTKVEELRQYLWRWGFYTPDRKYQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKSLTEIIPLTEEAE LELAENREILREPVHGVYYDPSKELIAEIQKQEQGQWTYQIYHEPFKNLKTGKYARTRGA HTNDVKQLAEVVQKIATESIVIWGKTPKFRLPIQRETWET |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |