Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3252 | 3252-30619 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L76V, I84V, L90M | L10F, L33F, L89V | I13V, L19LI, M36L, I62V, L63P, I66F, A71T, T91S |
| >3252-30619| codons 1-99 PQITLWQRPFVTVKIGGQIKEALLDTGADDTVFEELNLPGRWKPKIIGGIGGFIKVRQYD QVPIEFCGHKTIGTVVVGPTPVNVIGRNVMSQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K219N | K103N | F227L | K20R, E44D, V106I, V118I, D123E, S163A, V179T, I195IL, G196E, E203K, H208Y, R211K, K223E, Q278E, I293IV, E297R, Q334C, R356K, G359S, A371V, A376T, T386A, K390R, E399D |
| >3252-30619| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSITVLDVGDAYFSIPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSAMTKILEPFRKQNPDITI YQYVDDLYVGSDLELEQHRTKIKELRQYLWKWGFYTPDNKHQEEPPLLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKELCKLLRGTKALTEVVPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGCGQWTYQIYQEPFKNLKTGKYAKMRSA HTNDVKQLTEVVQKITTESIVIWGKAPKFRLPIQKETWDA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |