Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3251 | 3251-30630 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V82F, I84V | F53L | L10I, T12P, I13IV, K20KM, N37NHRS, K45I, I62V, L63P, I64V, A71V, I72V, V77I, P79A, Q92K |
| >3251-30630| codons 1-99 PQITLWQRPIVPVKIGGQLMEALLDTGADDTVLEEMSLPGRWKPIMIGGIGGLIKVRQYD QVPVEICGHKVVGTVLIGATPFNVIGRNLLTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | E6K, V35IL, T39E, E44D, V118I, K122E, I135T, E203K, H208Y, R211K, K223Q, A288S, V317A, Q334N, G359S, A371V, A376C, T377L, T386I, E399D |
| >3251-30630| codons 1-399 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALLEICEELEKDGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIKELRQYLWKWGFYTPDKKHQQEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKSLTEVIPLTEEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGNGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEVVQKICLESIVIWGKIPKFKLPIQKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |