<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3251 3251-30630 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V82F, I84V F53L L10I, T12P, I13IV, K20KM, N37NHRS, K45I, I62V, L63P, I64V, A71V, I72V, V77I, P79A, Q92K  
>3251-30630| codons 1-99
PQITLWQRPIVPVKIGGQLMEALLDTGADDTVLEEMSLPGRWKPIMIGGIGGLIKVRQYD
QVPVEICGHKVVGTVLIGATPFNVIGRNLLTKIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, M184V, L210W, T215Y       E6K, V35IL, T39E, E44D, V118I, K122E, I135T, E203K, H208Y, R211K, K223Q, A288S, V317A, Q334N, G359S, A371V, A376C, T377L, T386I, E399D  
>3251-30630| codons 1-399
PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALLEICEELEKDGKISKIGPENPYNTPV
FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRTKIKELRQYLWKWGFYTPDKKHQQEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKSLTEVIPLTEEAE
LELAENREILKEPVHGAYYDPSKDLIAEIQKQGNGQWTYQIYQEPFKNLKTGKYARMRSA
HTNDVKQLTEVVQKICLESIVIWGKIPKFKLPIQKETWD

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006