Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3250 | 3250-30627 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | L33IV, F53FL, G73S, L89V | L10V, V11L, I13V, K20M, A22V, M36I, R41K, K55KR, D60E, Q61N, I62V, L63P, A71I, I72T, I93L |
| >3250-30627| codons 1-99 PQITLWQRPVLTVKIGGQLMEVLLDTGADDTVVEEINLPGKWKPKMIGGIGGLVRVRQYE NVPIEICGHKITSTVLVGPTPANIIGRNVMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | K103N, Y181C | A98G, V108I | K20R, T39K, K43E, E44D, S68G, R83RK, V118I, K122E, S162A, T200A, E203K, Q207E, R211K, K223Q, L228R, I244IV, K281R, A288S, I293V, P294T, E297K, G333E, G359GS, K366R, T369V, E370D, A371V, I375V, K390R |
| >3250-30627| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICKELEEDGKISKIGPENPYNTPV FAIKKKDGTKWRKVVDFRELNKKTQDFWEVQLGIPHPGGLKKNKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIVI CQYVDDLYVGSDLEIGQHRAKIKELREHLWKWGFYTPDKKHQQEPPFRWMGYELHPDKWT VQPVVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCRLLRGTKSLTEVVTLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQEQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVRQLVDVVQKVATESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |