Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3249 | 3249-30617 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, T215F | K219Q, N348I | K103N | K238T | V60I, V118I, D121Y, K122E, I142T, R172K, Q174R, I178L, Q207E, F214L, L228H, T286A, E297A, Q334H, T338S, M357T |
| >3249-30617| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL YEDFRKYTAFTIPSINNETPGTRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKRNPDLVI YQYMDDLYVGSDLEIGQHRTKIEELREHLLRWGLFTPDQKHQKEPPFHWMGYELHPDTWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGHGQWSYQIYQEPFKILKTGKYARTRGA HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54L, I84V | Q58E | L10I, I15V, K20R, M36I, I62V, L63P, Q92R, I93L |
| >3249-30617| codons 1-99 PQITLWQRPIVTIKVGGQLREALLDTGADDTVLEEINLPGRWKPKLIGGIGGFLKVREYD QVPIEICGHKAIGTVLVGPTPVNVIGRNLLTRLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |