Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3246 | 3246-30616 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V, I54V, V82A, L90M | L33F, Q58E | L10IV, I13V, I15V, L19I, K20R, E35D, M36I, K55KR, R57K, L63P, K70KT, A71V, I93L |
| >3246-30616| codons 1-99 PQITLWQRPVVTVKVGGQIREALLDTGADDTVFEDINLPGRWKPKIIGGVGGFVRVKEYD QIPIEICGHTVIGTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML | P4PS, T39A, K122KE, Q174QK, G196GR, H208HY, V245I, A272S, K277R, T286A, E297A, E312AT, I329L, M357T, R358K, A376T, T386M, K390R, A400T |
| >3246-30616| codons 1-400 PISSIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPDIVI YQYMDDLYVGSDLEIRQHRTKIEELRQYLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIILPEKDSWTVNDIQKLVGKLNWASQIYSGIKVRQLCKLLRGAKALTEVIPLTAEAE LELAENREILKTPVHGVYYDPSKDLIAELQKQGQGQWTYQIYQEPFKNLKTGKYARTKGA HTNDVKQLTEAVQKITTESIVIWGKMPKFRLPIQKETWET |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |