<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3245 3245-30604 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, L74V, T215F K219R K103N, Y181C A98G, V108I E6K, V60I, T69E, V118I, K122E, I135T, I142V, V189I, G196E, F214L, D218E, H221Y, L228N, E297K, A304E, L325I, Q334L, R356K, G359S, A360T, A371V, I375V, K390R, E399D  
>3245-30604| codons 1-400
PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI
FAIKKKNSEKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTILDVGDAYFSIPL
DEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
CQYMDDLYIGSDLEIEQHRTKIEELRQHLLRWGLFTPERKYQKEPPFNWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVIPLTKEAE
LELEENREILKEPVHGVYYDPSKDIIAEIQKQGLGQWTYQIYQEPFKNLKTGKYAKMRST
HTNDVKQLTEVVQKVATESIVIWGKTPKFRLPIQKETWDA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I47V, I50L, L90M L33F, K43KT, G73T, L89V L10H, I13V, E35D, M36L, N37T, L63P, I64V, A71V, V77I, I93L  
>3245-30604| codons 1-99
PQITLWQRPHVTVKIGGQLKEALLDTGADDTIFEDLTLPGRWTPKIVGGLGGFIKVRQYD
QIPVEICGHKVITTVLIGPTPVNIIGRNVMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006