Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3245 | 3245-30604 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I50L, L90M | L33F, K43KT, G73T, L89V | L10H, I13V, E35D, M36L, N37T, L63P, I64V, A71V, V77I, I93L |
| >3245-30604| codons 1-99 PQITLWQRPHVTVKIGGQLKEALLDTGADDTIFEDLTLPGRWTPKIVGGLGGFIKVRQYD QIPVEICGHKVITTVLIGPTPVNIIGRNVMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, L74V, T215F | K219R | K103N, Y181C | A98G, V108I | E6K, V60I, T69E, V118I, K122E, I135T, I142V, V189I, G196E, F214L, D218E, H221Y, L228N, E297K, A304E, L325I, Q334L, R356K, G359S, A360T, A371V, I375V, K390R, E399D |
| >3245-30604| codons 1-400 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSEKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYIGSDLEIEQHRTKIEELRQHLLRWGLFTPERKYQKEPPFNWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVIPLTKEAE LELEENREILKEPVHGVYYDPSKDIIAEIQKQGLGQWTYQIYQEPFKNLKTGKYAKMRST HTNDVKQLTEVVQKVATESIVIWGKTPKFRLPIQKETWDA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |