<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3243 3243-30613 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I54V, V82AT, L90M K43IT L10I, T12K, L19I, R57K, L63P, A71T, I93FL, C95F  
>3243-30613| codons 1-99
PQITLWQRPIVKIKIGGQIKEALLDTGADDTVLEEMNLPGRWTPKMIVGIGGFVKVKQYD
QIPIEICGHKTIGTVLVGPTPTNIIGRNLMTQLGFTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K70R, L74LV, M184V D67G, K219EQ K103KN K238KT K20R, V35VI, K43KE, S68G, K122KE, I135T, S162A, T200A, E203EK, Q207E, D218DE, I270IV, T286A, E297K, I326V, G333E, Q334H, F346Y, G359GS, V365I, A371V, T377M  
>3243-30613| codons 1-400
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTEMEEEGKISKIGPENPYNTPV
FAIKKKGGTRWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRAKIKELREHLLRWGFTTPEQKHQKEPPFLWMGYELHPDTWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQVYAGIKVKQLCKLLRGAKALTEVIPLTKEAE
LELAENREILKEPVHGVYYDPSKDLVAEIQKQEHGQWTYQIYQEPYKNLKTGKYARMRSA
HTNDIKQLTEVVQKIAMESIVIWGKTPKFKLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006