Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3243 | 3243-30613 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54V, V82AT, L90M | K43IT | L10I, T12K, L19I, R57K, L63P, A71T, I93FL, C95F |
| >3243-30613| codons 1-99 PQITLWQRPIVKIKIGGQIKEALLDTGADDTVLEEMNLPGRWTPKMIVGIGGFVKVKQYD QIPIEICGHKTIGTVLVGPTPTNIIGRNLMTQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R, L74LV, M184V | D67G, K219EQ | K103KN | K238KT | K20R, V35VI, K43KE, S68G, K122KE, I135T, S162A, T200A, E203EK, Q207E, D218DE, I270IV, T286A, E297K, I326V, G333E, Q334H, F346Y, G359GS, V365I, A371V, T377M |
| >3243-30613| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTEMEEEGKISKIGPENPYNTPV FAIKKKGGTRWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKIKELREHLLRWGFTTPEQKHQKEPPFLWMGYELHPDTWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQVYAGIKVKQLCKLLRGAKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLVAEIQKQEHGQWTYQIYQEPYKNLKTGKYARMRSA HTNDIKQLTEVVQKIAMESIVIWGKTPKFKLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |