Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA2073 | CA7680 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDC | 48 |
| 2 | AZT+DDC+DDI | 26 |
| 3 | D4T+DDI+SQV | 31 |
| 4 | 3TC+AZT+IDV | 43 |
| 5 | D4T+DDI+IDV | 26 |
| 6 | 3TC+AZT+IDV | 69 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L10I, K20I, E35D, N37D, L63P, A71V, I72IL |
| >CA7680| codons 1-99 PQITLWQRPIVTIKIGGQLIEALLDTGADDTVLEDMDLPGRWKPKLIGGIGGFVKVRQYD QIPIEICGHKVLGTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219N | T27S, K43E, E44A, V118I, K122E, I142IV, A158S, I202V, R211K, A272P | N265NT, C280CR |
| >CA7679| codons 1-285 PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELEEAGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPSIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKVEELRQHLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLTWASQIYPGIKVKQLRKLLRG |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |