Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3239 | 3239-30521 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70KIR, L74I, M184MV, L210W, T215Y | L100I, K103N | K43Q, E44D, I94L, A98S, V111I, V189I, G196E, E203K, Q207DE, H208Y, R211K, E248D, K249KQ, A272P, K277R, T286A, E297K, R356K, K366R, A376C, V381I, K390R, K395R, E399D |
| >3239-30521| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEQDGKISKIGPENPYNTPV FAIKKKNSTRWRKIVDFRELNKRTQDFWEVQLGLPHPSGIKKNKSVTVLDIGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYIGSDLEIEQHRTKIKELREYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPDQDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRGA HTNDVRQLTEAVQKICTESIIIWGKTPKFRLPIQRETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L76V, I84V, L90M | L10F, L33F, Q58E | I13V, K20R, E35D, M36I, N37DE, R57RK, I62V, L63Q, I64V, L89M |
| >3239-30521| codons 1-99 PQITLWQRPFVTVKIGGQLREALLDTGADDTVFEDIELPGRWKPKIIGGIGGFIKVKEYD QVQVEICGHKAIGTVVVGPTPVNVIGRNMMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |