<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3238 3238-30521 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, V75M, L210W, T215FY N348I K101E, Y181C, G190AS E138K V35I, T39D, E40F, K43E, W88C, V118I, K122E, I135T, I142V, T200A, H208Y, R211N, H221Y, E224ED, L228H, I244IV, T286A, I293V, I329V, G335GS, R356K, E370A, T377Q, V381VI, T386I, K390KR  
>3238-30521| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICDFLEEEGKISKIGPENPYNTPV
FAIKKKNSTKWRKLMDFRELNKRTQDFCEVQLGIPHPAGLEKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSTNNKTPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
CQYMDDLYVSSDLEIGQHRAKIEELRQYLWNWGFYTPDKKYQKDPPFHWMGYELHPDKWT
VQPVVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEVQKQGQSQWTYQIYQEPFKILKTGKYAKMRGA
HTNDVKQLTAAVQKIAQESIIIWGKIPKFRLPIQKETWEA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I50V, I54A, V82A K43T L10V, I15V, K20R, E35D, M36I, I62V, L63P, A71V, T74S, I93L  
>3238-30521| codons 1-99
PQITLWQRPVVTIKVGGQLREALLDTGADDTVLEDINLPGRWTPKMIVGVGGFAKVRQYD
QVPIEICGHKVIGSVLVGPTPANIIGRNLLTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006