Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3238 | 3238-30521 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, L210W, T215FY | N348I | K101E, Y181C, G190AS | E138K | V35I, T39D, E40F, K43E, W88C, V118I, K122E, I135T, I142V, T200A, H208Y, R211N, H221Y, E224ED, L228H, I244IV, T286A, I293V, I329V, G335GS, R356K, E370A, T377Q, V381VI, T386I, K390KR |
| >3238-30521| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICDFLEEEGKISKIGPENPYNTPV FAIKKKNSTKWRKLMDFRELNKRTQDFCEVQLGIPHPAGLEKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNKTPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYVSSDLEIGQHRAKIEELRQYLWNWGFYTPDKKYQKDPPFHWMGYELHPDKWT VQPVVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQGQSQWTYQIYQEPFKILKTGKYAKMRGA HTNDVKQLTAAVQKIAQESIIIWGKIPKFRLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I50V, I54A, V82A | K43T | L10V, I15V, K20R, E35D, M36I, I62V, L63P, A71V, T74S, I93L |
| >3238-30521| codons 1-99 PQITLWQRPVVTIKVGGQLREALLDTGADDTVLEDINLPGRWTPKMIVGVGGFAKVRQYD QVPIEICGHKVIGSVLVGPTPANIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |