Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3236 | 3236-30526 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54LV, V82F, L90M | L33F, Q58E | L10V, I13V, I15V, G16E, K20R, E35D, M36I, R41RK, K55Q, I62V, L63C, I64V, V77VI, I93L |
| >3236-30526| codons 1-99 PQITLWQRPVVTVKVEGQLREALLDTGADDTVFEDINLPGKWKPKMIGGIGGFVQVREYD QVCVEICGHKAIGTVLIGPTPFNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70KR, V75M, L210W, T215Y | K219Q | Y181YC, G190GA | V35T, V60I, K101Q, K122KE, I135V, S162D, E203K, Q207D, H208Y, R211K, D218E, H221HY, L228H, A288S, I293V, L325I, I326V, Q334E, V365I, E370G, S379C, I382L, K395R, E399D |
| >3236-30526| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLMDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPDIVI CQYMDDLYVASDLEIGQHRTKIKELRDYLWKWGFYTPEQKYQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKSLTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDIVAEIQKQGEGQWTYQIYQEPFKNLKTGKYARMRGA HTNDIKQLTGAVQKIATECIVLWGKTPKFKLPIQRETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |