<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3235 3235-30521 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L74I, V75T, L210W, T215Y K219E K101E, Y181C, G190S   S3C, K43E, E44A, K49R, T69N, K122E, E138D, I142T, E169D, I178L, E203Q, Q207D, H208Y, R211K, D218E, L228H, A272AP, K277R, Q278H, T286A, E297R, Q334E, M357MR, G359S, K366R, T386IM, K390R, K395R, E399D  
>3235-30521| codons 1-399
PICPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEAGKISRIGPENPYNTPV
FAIKKKNSNRWRKITDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNDTPGTRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPDLVI
CQYMDDLYVSSDLEIGQHRTKIQELRDYLWKWGFYTPEEKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRHLCKLLRGAKALTEVIPLTREAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARRRSA
HTNDVRQLTEAVQKIATESIVIWGKMPKFRLPIQRETWD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, G48V, I54S, V82A G73ST L10I, N37D, F53Y, I62V, L63P, A71V, V77I, I93L  
>3235-30521| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKIIVGIGGYSKVRQYD
QVPIEICGHKVITTVLIGPTPANIIGRNLLTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006