Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3235 | 3235-30521 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, G48V, I54S, V82A | G73ST | L10I, N37D, F53Y, I62V, L63P, A71V, V77I, I93L |
| >3235-30521| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKIIVGIGGYSKVRQYD QVPIEICGHKVITTVLIGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, V75T, L210W, T215Y | K219E | K101E, Y181C, G190S | S3C, K43E, E44A, K49R, T69N, K122E, E138D, I142T, E169D, I178L, E203Q, Q207D, H208Y, R211K, D218E, L228H, A272AP, K277R, Q278H, T286A, E297R, Q334E, M357MR, G359S, K366R, T386IM, K390R, K395R, E399D |
| >3235-30521| codons 1-399 PICPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEAGKISRIGPENPYNTPV FAIKKKNSNRWRKITDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNDTPGTRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPDLVI CQYMDDLYVSSDLEIGQHRTKIQELRDYLWKWGFYTPEEKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRHLCKLLRGAKALTEVIPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARRRSA HTNDVRQLTEAVQKIATESIVIWGKMPKFRLPIQRETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |