Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3234 | 3234-30528 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54T, V82A, L90M | L33F, K43T | L10I, T12P, K14R, K20M, E34Q, E35D, M36I, N37D, I62V, L63P, I64V, A71T, I72IV, I93L |
| >3234-30528| codons 1-99 PQITLWQRPIVPIRIGGQLMEALLDTGADDTVFQDIDLPGRWTPKLIVGIGGFTKVRQYD QVPVEICGHKTVGTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74LIV, M184V, L210W, T215Y | T39A, K43KE, V118I, K122E, I135T, V179VI, E203K, Q207E, T286A, A288S, K311R, V317VE, S322T, G335GC, M357T, V365I, T386I, A400T |
| >3234-30528| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEEEGKISKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYVDDLYVGSDLEIGQHRTKIKELREHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKSLTEVIPLTEEAE LELAENREILREPVHGEYYDPTKDLIAEIQKQGQCQWTYQIYQEPFKNLKTGKYARTRGA HTNDIKQLTEAVQKIATESIVIWGKIPKFKLPIQKETWET |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |