Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3231 | 3231-30520 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54L, V82A, L90M | L33F, K43T, F53L, G73S | L10V, I13V, G16A, K20R, E35D, M36I, R57RK, I62V, L63P, I66V, A71V |
| >3231-30520| codons 1-99 PQITLWQRPVVTVKIAGQLREALLDTGADDTIFEDINLPGRWTPKIVGGIGGLLKVKQYD QVPIEVCGHKVISTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69~, L74V, M184V, T215Y | K219E | L100I, Y188L | T39S, S68G, K122E, E138A, S162C, S163I, Q197K, R211K, D218E, V245M, A272P, R284K, T286P, E297R, I326V, Q334E, M357T, R358K, T377K, E399D |
| >3231-30520| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICSELEKEGKISKIGPENPYNTPV FAIKKKNG~KWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSPAIFQCIMTKILEPFRKQNPDIVI YQYVDDLLVGSDLEIGKHRTKIEELRQHLLKWGFYTPEEKHQKEPPFLWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLKGPKALTEVIPLTREAE LELAENREILKEPVHGVYYDPSKDLVAEIQKQGEGQWTYQIYQEPFKNLKTGKYARTKGA HTNDVKQLTEAVQKIAKESIVIWGKTPKFKLPIQKETWDA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |