Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3229 | 3229-30523 | France | 2003 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, I84V | L10F, L24I, L33F, K43T | T12S, I13V, L19I, K20M, E35D, M36I, R41K, L63V, I64V, H69K, T74S, L89I, T91S |
| >3229-30523| codons 1-99 PQITLWQRPFVSVKIGGQIMEALIDTGADDTVFEDINLPGKWTPKIIGGIGGFVKVRQYD QIVVEICGKKAIGSVLVGPTPANVIGRNILSQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, V75M, M184V, L210W, T215Y | V106M, Y188L | V108I | E28K, V35T, T39E, E44D, S48T, V60I, S68R, L109V, V118I, K122E, D123S, I135V, S162N, K173T, Q174K, V189I, G196E, T200A, Q207E, R211K, D218E, V245K, D250E, S251D, A272P, V292I, I293V, E297K, Q334L, G335D, R356K, G359T, K366R, A371V, T377L, K390R, K395R |
| >3229-30523| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTKEKIKALTEICEELEKDGKITKIGPENPYNTPI FAIKKKNRDKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKKKSMTIVDVGDAYFSIPL DESFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQNSMTKILEPFRTKNPDIVI YQYVDDLLIGSDLEIEQHRAKIEELREHLWKWGFYTPEKKHQKEPPFLWMGYELHPDKWT VQPIKLPEKEDWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEIVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLDQWTYQIYQEPFKNLKTGKYAKMRTA HTNDVRQLTEVVQKIALESIVIWGKTPKFRLPIQRETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |