<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3229 3229-30523 France 2003 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A, I84V L10F, L24I, L33F, K43T T12S, I13V, L19I, K20M, E35D, M36I, R41K, L63V, I64V, H69K, T74S, L89I, T91S  
>3229-30523| codons 1-99
PQITLWQRPFVSVKIGGQIMEALIDTGADDTVFEDINLPGKWTPKIIGGIGGFVKVRQYD
QIVVEICGKKAIGSVLVGPTPANVIGRNILSQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, V75M, M184V, L210W, T215Y   V106M, Y188L V108I E28K, V35T, T39E, E44D, S48T, V60I, S68R, L109V, V118I, K122E, D123S, I135V, S162N, K173T, Q174K, V189I, G196E, T200A, Q207E, R211K, D218E, V245K, D250E, S251D, A272P, V292I, I293V, E297K, Q334L, G335D, R356K, G359T, K366R, A371V, T377L, K390R, K395R  
>3229-30523| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTKEKIKALTEICEELEKDGKITKIGPENPYNTPI
FAIKKKNRDKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKKKSMTIVDVGDAYFSIPL
DESFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQNSMTKILEPFRTKNPDIVI
YQYVDDLLIGSDLEIEQHRAKIEELREHLWKWGFYTPEKKHQKEPPFLWMGYELHPDKWT
VQPIKLPEKEDWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEIVPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLDQWTYQIYQEPFKNLKTGKYAKMRTA
HTNDVRQLTEVVQKIALESIVIWGKTPKFRLPIQRETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006