<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3228 3228-30523 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, K70R, L74V, M184V, T215F K219Q K103N, Y181C A98G, V108I, Y318YF V35T, V60I, V118I, D123E, I135T, T139K, G196E, F214L, L228H, I270V, A272P, K275KR, V276T, L279M, E297K, F346Y, M357V, A360V, A376S, E396D, E399D  
>3228-30523| codons 2-399
ISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEKEGKISKIGPENPYNTPIF
AIKKKNSDRWRKVVDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTILDVGDAYFSIPLD
KEFRKYTAFTIPSTNNEKPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIC
QYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGLFTPDQKHQKEPPFHWMGYELHPDKWTV
QPIVLPEKDSWTVNDIQKLVGKLNWASQVYPGIRTKQMCKLLRGTKALTEVIPLTKEAEL
ELAENREILKEPVHGVFYDPSKDLIAEIQKQGQGQWTYQIYQEPYKNLKTGKYARVRGVH
TNDVKQLTEAVQKISTESIVIWGKTPKFKLPIQKDTWD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, G48V, I54A, V82A, L90M   L10V, T12P, K14R, N37ND, L63P, A71V, V77I, I93L  
>3228-30523| codons 1-99
PQITLWQRPVVPIRIGGQLKEALLDTGADDTVLEEMDLPGRWKPKLIVGIGGFAKVRQYD
QIPIEICGHKVIGTVLIGPTPANIIGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006