Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3228 | 3228-30523 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54A, V82A, L90M | L10V, T12P, K14R, N37ND, L63P, A71V, V77I, I93L |
| >3228-30523| codons 1-99 PQITLWQRPVVPIRIGGQLKEALLDTGADDTVLEEMDLPGRWKPKLIVGIGGFAKVRQYD QIPIEICGHKVIGTVLIGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, L74V, M184V, T215F | K219Q | K103N, Y181C | A98G, V108I, Y318YF | V35T, V60I, V118I, D123E, I135T, T139K, G196E, F214L, L228H, I270V, A272P, K275KR, V276T, L279M, E297K, F346Y, M357V, A360V, A376S, E396D, E399D |
| >3228-30523| codons 2-399 ISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEKEGKISKIGPENPYNTPIF AIKKKNSDRWRKVVDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTILDVGDAYFSIPLD KEFRKYTAFTIPSTNNEKPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIC QYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGLFTPDQKHQKEPPFHWMGYELHPDKWTV QPIVLPEKDSWTVNDIQKLVGKLNWASQVYPGIRTKQMCKLLRGTKALTEVIPLTKEAEL ELAENREILKEPVHGVFYDPSKDLIAEIQKQGQGQWTYQIYQEPYKNLKTGKYARVRGVH TNDVKQLTEAVQKISTESIVIWGKTPKFKLPIQKDTWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |