Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3227 | 3227-30521 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, I47V, G48M, I54M, V82A, L90M | L33F, F53L | L10I, I13V, Q18H, L19T, K20KT, M36MI, N37S, L63P, A71V, I93L, C95F |
| >3227-30521| codons 1-99 PQITLWQRPIVTVKIGGHTTEALLDTGADDTIFEEISLPGRWKPKMVMGIGGLMKVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLMTQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R, M184V, T215F | D67S, K219E | K101E, Y181C, G190A | A98G, V108I | P4T, E28A, K64R, T69N, V179I, R211K, T286A, I293IV, Q334L, R358K, T369V, T377Q, K385R, K390R | L228S |
| >3227-30521| codons 1-400 PISTIETVPVKLKPGMDGPKVKQWPLTAEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIRKKSSNRWRKLVDFRELNKRTQDFWEVQLGIPHPGGLEKKKSVTILDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII CQYVDDLYVASDLEIGQHRTKIEELRQHLLKWGFFTPDEKHQKEPPFSWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLGQWTYQIYQEPFKNLKTGKYARMKGA HTNDVKQLVEAVQKIAQESIVIWGRTPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |