<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3226 3226-30521 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, K70R, L74V, M184V, T215F K219Q K103S, Y181C   V35M, K64H, T69N, V118I, K122E, D123N, I135T, V179I, F214L, D218E, L228H, I293V, E297EA, I326V, I329V, F346Y, G359S, V365I, A371V, K388KR, K390R  
>3226-30521| codons 2-399
ISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTEMEKEGKISKIGPENPYNTPVF
AIHKKNSNRWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKSKSVTVLDVGDAYFSIPLD
ENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIIIC
QYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGLFTPEQKHQKEPPFHWMGYELHPDKWTV
QPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTAEAEL
ELAENREILKEPVHGVYYDPSKDLVAEVQKQGQGQWTYQIYQEPYKNLKTGKYARMRSAH
TNDIKQLTEVVQKIATESIVIWGKTPRFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M L10F, G73T L19V, K20R, E35D, M36I, I62V, L63P, I66V, A71V, V77T, I93L  
>3226-30521| codons 1-99
PQITLWQRPFVTIKIGGQVREALLDTGADDTVLEDINLPGRWKPKIIGGIGGFVKVRQYD
QVPIEVCGHKVITTVLTGPTPVNVIGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006