Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3226 | 3226-30521 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, L74V, M184V, T215F | K219Q | K103S, Y181C | P1L, V35M, K64H, T69N, V118I, K122E, D123N, I135T, V179I, F214L, D218E, L228H, I293V, E297EA, I326V, I329V, F346Y, G359S, V365I, A371V, K388KR, K390R, A400T |
| >3226-30521| codons 1-400 LISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTEMEKEGKISKIGPENPYNTPV FAIHKKNSNRWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKSKSVTVLDVGDAYFSIPL DENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII CQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGLFTPEQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTAEAE LELAENREILKEPVHGVYYDPSKDLVAEVQKQGQGQWTYQIYQEPYKNLKTGKYARMRSA HTNDIKQLTEVVQKIATESIVIWGKTPRFRLPIQKETWET |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, G73T | L19V, K20R, E35D, M36I, I62V, L63P, I66V, A71V, V77T, I93L |
| >3226-30521| codons 1-99 PQITLWQRPFVTIKIGGQVREALLDTGADDTVLEDINLPGRWKPKIIGGIGGFVKVRQYD QVPIEVCGHKVITTVLTGPTPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |