Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3225 | 3225-30521 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | K219N | G190A | V118I, K122E, V179I, Q197K, E203D, H208Y, R211RK, L228H, A272P, K275R, K281KR, A288S, E297K, Q334QL, T369V, E370ED, A371V, I375V, K390R |
| >3225-30521| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYVDDLYVASDLEIGKHRTKIDELRQYLWKWGFYTPDNKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVKQLCRLLRGTKSLTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLVDVVQKVATESIVIWGKTPKFRLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L23I, L33F, K43T, F53L, T74P | L10I, I13V, L19I, K20R, E35D, M36I, N37T, K55R, I62V, L63T, C67E, I72T, L89M |
| >3225-30521| codons 1-99 PQITLWQRPIVTVKIGGQIREAILDTGADDTVFEDITLPGRWTPKLIGGIGGLVRVRQYD QVTIEIEGHKATGPVLVGPTPANIIGRNMMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |