Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3224 | 3224-30624 | France | 2003 | HIV1 | CRF02_AG | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V, L210W, T215Y | Y188L | V35T, E36D, T39A, V90VI, V118I, K122P, I135V, T139A, S162A, Q174E, D177E, T200A, E203K, Q207E, K223E, V245Q, K277R, L283I, R284K, T286A, E291D, V292I, I293V, P294T, S322T, I326V, G335D, R356K, M357R, G359S, A371V, I375V, K390R, K395R, E399D |
| >3224-30624| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTDICAEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DPDFRKYTAFTIPSVNNEAPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKENPEIVI YQYVDDLLVGSDLEIGQHRAKIKELREHLWRWGFYTPDKKHQEEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLIKGAKALTDIVTLTEEAE LELAENREILKEPVHGVYYDPTKDLVAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKRRSA HTNDVKQLTEVVQKVATESIVIWGKTPKFRLPIQRETWDA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47IV, L76V, I84V | L33LI, Q58E | L10I, I13A, K20I, A22V, M36I, R41K, L63P, I66F, H69K, K70R, L89I, T91S |
| >3224-30624| codons 1-99 PQITLWQRPIVTAKIGGQLIEVLLDTGADDTVIEEINLPGKWKPKIVGGIGGFIKVREYD QIPIEFCGKRAIGTVVVGPTPVNVIGRNILSQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |