Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3223 | 3223-30610 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70KR, M184V, T215Y | K219Q | K101E | T39A, V60I, K122E, T139M, I142IV, I178M, R211K, A272P, T286TA, I293V, D324E, Q334C, G359S, A371V, A376S, T386TI, K390R |
| >3223-30610| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNEMPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGFYTPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGCGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEVVQKISTESIVIWGKIPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10I, I15V, G16A, K20I, N37D, L63P, I85V, Q92K |
| >3223-30610| codons 1-99 PQITLWQRPIVTIKVAGQLIEALLDTGADDTVLEEMDLPGRWKPKIIGGIGGFVKVRQYD QIPIEICGHKAIGTVLVGPTPVNVVGRNLMTKIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |