<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3221 3221-30522 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I47V, I54V, V82A, L90M L10F, V11VI, L33F, G73S T12Q, I13V, I15V, G16A, L19I, L63P, A71V, V77VI, I93L  
>3221-30522| codons 1-99
PQITLWQRPFIQVKVAGQIKEALLDTGADDTIFEEMNLPGRWKPKIVGGIGGFVKVRQYD
QIPIEICGHKVISTVLIGPTPANIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, M184I, L210W, T215Y K219R Y188L   P4PT, E6EA, V21I, T27TS, K43N, E44D, V90VI, V118I, K122E, I135T, S162Y, D177E, V179I, V189I, T200A, E203K, Q207E, H208Y, R211K, K223E, L228H, Q242H, K277R, T286A, A288T, E297K, D324E, Q334QL, K350R, K390R  
>3221-30522| codons 1-399
PISTIATVPVKLKPGMDGPKIKQWPLSEEKIKALVEICTELENDGKISKIGPENPYNTPV
FAIKKKNSDKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPEIII
YQYIDDLLIGSDLEIGQHRAKIKELREYLWKWGFYTPDRKHQEEPPFHWMGYELHPDKWT
VHPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKTLTEVIPLTKEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGLGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006