Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3221 | 3221-30522 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54V, V82A, L90M | L10F, V11VI, L33F, G73S | T12Q, I13V, I15V, G16A, L19I, L63P, A71V, V77VI, I93L |
| >3221-30522| codons 1-99 PQITLWQRPFIQVKVAGQIKEALLDTGADDTIFEEMNLPGRWKPKIVGGIGGFVKVRQYD QIPIEICGHKVISTVLIGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184I, L210W, T215Y | K219R | Y188L | P4PT, E6EA, V21I, T27TS, K43N, E44D, V90VI, V118I, K122E, I135T, S162Y, D177E, V179I, V189I, T200A, E203K, Q207E, H208Y, R211K, K223E, L228H, Q242H, K277R, T286A, A288T, E297K, D324E, Q334QL, K350R, K390R |
| >3221-30522| codons 1-399 PISTIATVPVKLKPGMDGPKIKQWPLSEEKIKALVEICTELENDGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPEIII YQYIDDLLIGSDLEIGQHRAKIKELREYLWKWGFYTPDRKHQEEPPFHWMGYELHPDKWT VHPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKTLTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGLGQWTYQIYQEPFKNLRTGKYARMRGA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |