Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3220 | 3220-30519 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | I13IV, E34ED, E35D, M36I, L63P, I72IV |
| >3220-30519| codons 1-99 PQITLWQRPLVTVKIGGQLKEALLDTGADNTVLDDINLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAVGTVLVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T215Y | K103N | P225H | T39A, I135L, E138A, I142V, Q174R, T200A, R211K, T286A, E297K, K311R, R356K, K390R, I393M, A400AT |
| >3220-30519| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSLNNATPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRQHLLKWGFYTPDKKHQKEHPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTKEAE LELAENREILREPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRGA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPMQKETWET |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |