<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3215 3215-30514 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, V75M, M184V, L210W, T215Y K219N, N348I L100I, K103N   E6D, E28K, I31L, K32E, K43E, E44A, V60I, I94L, V118I, K122E, D123DN, T200A, E203D, H208Y, R211K, L228H, K249Q, A272P, K277R, A288S, I293V, I326V, Q334L, R356RK, M357T, A376V, E378Q, V381I, E399D  
>3215-30514| codons 1-399
PISPIDTVPVKLKPGMDGPKVKQWPLTKEKLEALVEICTELEEAGKISKIGPENPYNTPI
FAIKKKNSTKWRKVMDFRELNKRTQDFWEVQLGLPHPAGIKKNKSVTVLDVGDAYFSIPL
DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRAKIDELRQYLWKWGFYTPDNKHQKEPPFHWMGYELHPDKWT
VQPIVLPEQDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKSLTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLVAEIQKQGLGQWTYQIYQEPFKILKTGKYAKTRGA
HTNDVKQLTEAVQKIVTQSIIIWGKTPKFKLPIQKETWD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I47V, I54M, I84V, L90M L10F, L33F, F53L, T74P, L89V I13V, L19V, K20R, E35D, M36I, N37D, L63C, I66F, A71V  
>3215-30514| codons 1-99
PQITLWQRPFVTVKIGGQVREALLDTGADDTIFEDIDLPGRWKPKIVGGIGGLMKVRQYD
QICIEFCGHKVIGPVLVGPTPVNVIGRNVMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006