Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3215 | 3215-30514 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, V75M, M184V, L210W, T215Y | K219N, N348I | L100I, K103N | E6D, E28K, I31L, K32E, K43E, E44A, V60I, I94L, V118I, K122E, D123DN, T200A, E203D, H208Y, R211K, L228H, K249Q, A272P, K277R, A288S, I293V, I326V, Q334L, R356RK, M357T, A376V, E378Q, V381I, E399D |
| >3215-30514| codons 1-399 PISPIDTVPVKLKPGMDGPKVKQWPLTKEKLEALVEICTELEEAGKISKIGPENPYNTPI FAIKKKNSTKWRKVMDFRELNKRTQDFWEVQLGLPHPAGIKKNKSVTVLDVGDAYFSIPL DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKIDELRQYLWKWGFYTPDNKHQKEPPFHWMGYELHPDKWT VQPIVLPEQDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKSLTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLVAEIQKQGLGQWTYQIYQEPFKILKTGKYAKTRGA HTNDVKQLTEAVQKIVTQSIIIWGKTPKFKLPIQKETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, I84V, L90M | L10F, L33F, F53L, T74P, L89V | I13V, L19V, K20R, E35D, M36I, N37D, L63C, I66F, A71V |
| >3215-30514| codons 1-99 PQITLWQRPFVTVKIGGQVREALLDTGADDTIFEDIDLPGRWKPKIVGGIGGLMKVRQYD QICIEFCGHKVIGPVLVGPTPVNVIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |