Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3211 | 3211-30731 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54V, V82S | L24I | L10I, E34Q, M36V, I62V, L63P, A71V, I72V, I93L |
| >3211-30731| codons 1-99 PQITLWQRPIVTIKIGGQLKEALIDTGADDTVLQEVNLPGRWKPKLIVGIGGFVKVRQYD QVPIEICGHKVVGTVLVGPTPSNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K103N | A98G, V108I, K238T | K11R, V35M, T39A, K43KE, R83K, V118I, D123E, S163C, D177E, V189VI, Q207E, R211K, A272P, D324DE, R356K, K366R |
| >3211-30731| codons 1-399 PISPIETVPVRLKPGMDGPKVKQWPLTEEKIKALMEICAELEEEGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKKTQDFWEVQLGIPHPGGLKKNKSVTILDVGDAYFSIPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSCMTKILEPFRKQNPEIVI YQYVDDLYIGSDLEIGQHRTKIEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDTWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRGA HTNDVRQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |