<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3210 3210-30515 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70KR, L74I, M184V, L210W, T215Y K219E K103KN, Y181C V108I T39A, T69N, K122E, I135T, E203K, Q207E, R211K, D218E, L228H, A272G, T286A, E291EA, I293V, I329L, G333E, R356K, M357T, A360IV, A376CS, E378EQ, T386I S163V
>3210-30515| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPV
FAIKKKNSNRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSVMTKILEPFRKQNPDIVI
CQYVDDLYVGSDLEIGQHRTKIKELREHLWKWGFYTPEEKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYGGIKVKQLCKLLRGAKALTAVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAELQKQEQGQWTYQIYQEPFKNLKTGKYAKTRGV
HTNDVKQLTEAVQKISTQSIVIWGKIPKFKLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I50V, I54V, V82T, L90M L33F, G73GS, L89V L10I, T12S, I13V, I15V, L19P, K20M, E21Q, E35D, M36I, R41K, I62V, L63P, I66F, A71V, Q92K  
>3210-30515| codons 1-99
PQITLWQRPIVSVKVGGQPMQALLDTGADDTVFEDINLPGKWKPKIIGGVGGFVKVRQYD
QVPIEFCGHKVISTVLVGPTPTNIIGRNVMTKIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006