Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3210 | 3210-30515 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V, I54V, V82T, L90M | L33F, G73GS, L89V | L10I, T12S, I13V, I15V, L19P, K20M, E21Q, E35D, M36I, R41K, I62V, L63P, I66F, A71V, Q92K |
| >3210-30515| codons 1-99 PQITLWQRPIVSVKVGGQPMQALLDTGADDTVFEDINLPGKWKPKIIGGVGGFVKVRQYD QVPIEFCGHKVISTVLVGPTPTNIIGRNVMTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70KR, L74I, M184V, L210W, T215Y | K219E | K103KN, Y181C | V108I | T39A, T69N, K122E, I135T, E203K, Q207E, R211K, D218E, L228H, A272G, T286A, E291EA, I293V, I329L, G333E, R356K, M357T, A360IV, A376CS, E378EQ, T386I | S163V |
| >3210-30515| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPV FAIKKKNSNRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSVMTKILEPFRKQNPDIVI CQYVDDLYVGSDLEIGQHRTKIKELREHLWKWGFYTPEEKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYGGIKVKQLCKLLRGAKALTAVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAELQKQEQGQWTYQIYQEPFKNLKTGKYAKTRGV HTNDVKQLTEAVQKISTQSIVIWGKIPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |